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Research

2014

Ito-Miwa, K., Serikawa, M., Kondo, T., Oyama, T.
Overexpression of a CO homologue disrupts the rhythmic expression of clock gene LgLHYH1 in Lemna gibba.
Plant Biotechnology. 31(4),319-328 (2014).

Nishiwaki-Ohkawa T, Kitayama Y, Ochiai E, Kondo T.
Exchange of ADP with ATP in the CII ATPase domain promotes autophosphorylation of cyanobacterial clock protein KaiC.
Proc.Natl.Acad.Sci.USA. 111,4455-4460 (2014).

2013

Kitayama Y, Nishiwaki-Ohkawa T, Sugisawa Y, Kondo T.
KaiC intersubunit communication facilitates robustness of circadian rhythms in cyanobacteria.
Nature Communications 4. Article No.2897, (2013).

Imai K, Kitayama Y, Kondo T.
Elucidation of the Role of Clp Protease Components in Circadian Rhythm by Genetic Deletion and Overexpression in Cyanobacteria.
J. Bacteriology. 195(19), 4517-4526 (2013).

2012

Nishiwaki T, Kondo T.
Circadian Autodephosphorylation of Cyanobacterial Clock Protein KaiC Occurs via Formation of ATP as Intermediate.
J. Biol. Chem. 287, 18030-18035 (2012).

2011

Murayama Y*, Mukaiyama A*, Imai K*, Onoue Y, Tsunoda A, Nohara A, Ishida T, Maeda Y, Terauchi K, Kondo T, Akiyama S.
(*equally-contributed)
Tracking and visualizing the circadian ticking of the cyanobacterial clock protein KaiC in solution.
EMBO J. 30, 68-78 (2011).

2010

Nakajima M*, Ito H*, Kondo T.
(*equally-contributed)
In vitro Regulation of Circadian Phosphorylation Rhythm of Cyanobacterial Clock Protein KaiC by KaiA and KaiB.
FEBS Lett. 584, 898-902 (2010).

Taniguchi Y*, Takai N*, Katayama M, Kondo T, Oyama T.
(*equally-contributed)
Three major output pathways from the KaiABC-based oscillator cooperate to generate robust circadian kaiBC expression in cyanobacteria
Proc. Natl Acad. Sci. USA. 107, 3263-3268 (2010).

2009

Ito H*, Mutsuda M, Murayama Y, Tomita J, Hosokawa N, Terauchi K, Sugita C, Sugita M, Kondo T, Iwasaki H*.
(*equally-contributed)
Cyanobacterial daily life with Kai-based circadian and diurnal genome-wide transcriptional control in Synechococcus elongatus
Proc. Natl Acad. Sci. USA. 106, 14168-14173 (2009).

Yoshida T*, Murayama Y*, Ito H*, Kageyama H, Kondo T.
(*equally-contributed)
Nonparametric entrainment of the in vitro circadian phosphorylation rhythm of cyanobacterial KaiC by temperature cycle.
Proc. Natl Acad. Sci. USA. 106, 1648-1653 (2009).

2008

Kitayama Y, Nishiwaki T, Terauchi K, Kondo T.
Dual KaiC-based oscillations constitute the circadian system of cyanobacteria.
Genes & Development. 22, 1513-1521 (2008).

Serikawa M, Miwa K, Kondo T, Oyama T.
Functional conservation of clock-related genes in flowering plants: overexpression and RNAi analyses of the circadian rhythm in the monocotyledon Lemna gibba.
Plant Physiol. 146, 1952-1963 (2008).

Murayama Y, Oyama T, Kondo T.
Regulation of Circadian Clock Gene Expression by Phosphorylation States of KaiC in Cyanobacteria.
J. Bacteriol. 190, 1691-1698 (2008).

2007

Ito H, Kageyama H, Mutsuda M, Nakajima M, Oyama T, Kondo T.
Autonomous synchronization of the circadian KaiC phosphorylation rhythm.
Nature Struct. Mol. Biol. 14, 1084-1088 (2007).

Terauchi K*, Kitayama Y*, Nishiwaki T, Miwa K, Murayama Y, Oyama T, Kondo T.(*equally-contributed)
ATPase activity of KaiC determines the basic timing for circadian clock of cyanobacteria.
Proc. Natl Acad. Sci. USA. 104, 16377-16381 (2007).

Nishiwaki T*, Satomi Y*, Kitayama Y*, Terauchi K, Kiyohara R, Takao T, Kondo T.(*equally-contributed)
A sequential program of dual phosphorylation of KaiC as a basis for circadian rhythm in cyanobacteria.
EMBO J. 26, 4029-4037 (2007).

Kutsuna S, Kondo T, Ikegami H, Uzumaki T, Katayama M, Ishiura M.
The Circadian Clock-Related Gene pex Regulates a Negative cis Element in the kaiA Promoter Region.
J Bacteriol 189, 7690-7696 (2007).

Yamanaka I, Koinuma S, Shigeyoshi Y, Uchiyama Y, Yagita K.
Presence of robust circadian clock oscillation under constitutive over-expression of mCry1 in rat-1 fibroblasts.
FBES Lett. 581, 4098-4102 (2007).

Taniguchi Y, Katayama M, Ito R, Takai N, Kondo T, Oyama T.
labA: a novel gene required for negative feedback regulation of the cyanobacterial circadian clock protein KaiC.
Genes Dev. 21, 60-70 (2007).

2006

Kiyohara YB, Tagao S, Tamanini F, Morita A, Sugisawa Y, Yasuda M, Yamanaka I, Ueda HR, van der Horst GTJ, Kondo T, Yagita K.
The BMAL1 C terminus regulates the circadian transcription feedback loop.
Proc. Natl Acad. Sci. USA. 103, 10074-9 (2006).

Miwa K, Serikawa M, Suzuki S, Kondo T and Oyama T.
Conserved expression profiles of circadian clock-related genes in two Lemna species showing long-day and short-day photoperiodic flowering responses.
Plant Cell Physiol. 47,601-12 (2006).

Kageyama H, Nishiwaki T, Nakajima M, Iwasaki H, Oyama T, Kondo T.
Cyanobacterial circadian pacemaker: Kai protein complex dynamics in the KaiC phosphorylation cycle in vitro.
Mol. Cell 23, 161-71 (2006).

Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
Proc. Natl Acad Sci. USA. 103, 12109-14 (2006).

Nishii K, Yamanaka I, Yasuda M, Kiyohara YB, Kitayama Y, Kondo T, Yagita K
Rhythmic post-transcriptional regulation of the circadian clock protein mPER2 in mammalian cells: a real-time analysis.
Neurosci Lett. 401, 44-8 (2006).

2005

Hitomi K, Oyama T*, Han S, Arvai AS, Getzoff ED* (* co-corresponding authors)
Tetrameric Architecture of the Circadian Clock Protein KaiB:A Novel Interface for Intermolecular Interactions and Its Impact on the Circadian Rhythm
J. Biol. Chem. 280, 19127-35 (2005).

Kiyohara YB, Katayama M, Kondo T.
A novel mutation in kaiC affects resetting of the cyanobacterial circadian clock.
J. Bacteriol. 187(8),2559-64 (2005).

Nakajima M, Imai K, Ito H, Nishiwaki T, Murayama Y, Iwasaki H, Oyama T, and Kondo T
Reconstitution of Circadian Oscillation of Cyanobacterial KaiC Phosphorylation in Vitro
Science 308, 5720: 414-415 (2005).

Tomita J, Nakajima M, Kondo T, Iwasaki H
No transcription-translation feedback in circadian rhythm of KaiC phosphorylation.
Science 307, 5707: 251-254 (2005).

2004

Nishiwaki T, Satomi Y, Nakajima M, Lee C, Kiyohara R, Kageyama H, Kitayama Y, Temamoto M, Yamaguchi A, Hijikata A, Go M, Iwasaki H, Takao T, Kondo T.
Role of KaiC phosphorylation in the circadian clock system of Synechococcus elongatus PCC 7942.
Proc. Natl Acad. Sci. USA. 101,13927-32 (2004).

Imai K, Nishiwaki T, Kondo T, Iwasaki H.
Circadian rhythms in the synthesis and degradation of a master clock protein KaiC in cyanobacteria.
J. Biol. Chem. 279, 36534-36539 (2004).

Nakahira Y, Katayama M, Miyashita H, Kutsuna S, Iwasaki H, Oyama T, Kondo T
Global gene repression by KaiC as a master process of prokaryotic circadian system.
Proc. Natl. Acad. Sci. USA. 101, 881-885 (2004).

Kitayama Y, Kondo T, Nakahira Y, Nishimura H, Ohmiya Y, Oyama T
An in vivo dual-reporter system of cyanobacteria using two railroad-worm luciferases with different color emissions.
Plant Cell Physiol. 45, 109-113 (2004).

Nakamichi N, Ito S, Oyama T, Yamashino T, Kondo T, Mizuno T
Characterization of plant circadian rhythms by employing Arabidopsis cultured cells with bioluminescence reporters.
Plant Cell Physiol. 45, 57-67 (2004).

Iwasaki H, Kondo T.
Circadian timing mechanism in the prokaryotic clock system of cyanobacteria.
J. Biol. Rhythms 19, 436-444 (2004).

2003

Kitayama Y, Iwasaki H, Nishiwaki T, Kondo T
KaiB functions as an attenuator of KaiC phosphorylation in the cyanobacterial circadian clock system.
EMBO J. 22, 2127-2134 (2003).

Kageyama H, Kondo T, Iwasaki H
Circadian formation of clock protein complexes by KaiA, KaiB, KaiC, and SasA in cyanobacteria.
J. Biol. Chem. 278, 2388-2395 (2003).

2002

Iwasaki H, Nishiwaki T, Kitayama Y, Nakajima M, Kondo T
KaiA-stimulated KaiC phosphorylation in circadian timing loops in cyanobacteria.
Proc. Natl. Acad. Sci. USA. 99, 15788-15793 (2002).

Nishimura H, Nakahira Y, Imai K, Tsuruhara A, Kondo H, Hayashi H, Hirai M, Saito H, Kondo T
Mutations in KaiA, a clock protein, extend the period of circadian rhythm of cyanobacterium Synechococcus elogatus PCC7942.
Microbiology 148, 2903-2909 (2002).

2001

Taniguchi Y, Yamaguchi A, Hijikata A, Iwasaki H, Kamagata K, Ishiura M, Go M, Kondo T
Two KaiA-binding domains of cyanobacterial circadian clock protein KaiC.
FEBS lett. 496, 86-90, (2001).

2000

Iwasaki H, Williams SB, Kitayama Y, Ishiura M, Golden SS, Kondo T
A KaiC-interacting sensory histidine kinase, SasA, necessary to sustain robust circadian oscillation in cyanobacteria.
Cell 101, 223-233 (2000).

Nishiwaki T, Iwasaki H, Ishiura M, Kondo T
Nucleotide binding and autophosphorylation of the clock protein KaiC as a circadian timing process of cyanobacteria.
Proc Natl Acad Sci USA 97, 495-499 (2000).

Schmitz O, Katayama M, Williams SB, Kondo T, Golden SS
CikA, a bacteriophytochrome that resets the cyanobacterial circadian clock.
Science 289, 765-768 (2000).

Iwasaki H, Kondo T
The current state and problems of circadian clock studies in cyanobacteria.
Plant Cell Physiol. 41, 1013-1020 (2000).

Kondo T, Ishiura M
Circadian clock ofcyanobacteria.
BioEssays 22, 10-15 (2000).

S Hirota, K Hayamizu, T Okuno, M Kishi, H Iwasaki, T Kondo, T Hibino, T Takabe, T Kohzuma, O Yamauchi
Spectroscopic and electrochemical studies on structural change of plastocyanin and its tyrosine 83 mutants induced by interaction with lysine peptides
Biochemistry, 39, 6357-6364 (2000).

1999ȑO

Kondo T, Ishiura M
The circadian clocks of plants and cyanobacteria.
Trends Plant Sci. 4, 171-176 (1999).

Iwasaki H, Taniguchi Y, Ishiura M, Kondo T
Physical interactions among circadian clock proteins, KaiA, KaiB and KaiC, in cyanobacteria.
EMBO J. 18, 1137-1145 (1999).

Katayama M, TsinoremasNF, Kondo T, Golden SS
cpmA, a gene involved in an output pathway of the cyanobacterial circadian system.
J Bacteriol 181, 3516-3524 (1999).

NJ Cosper, C Stalhandske, H Iwasaki, T Oshima, R Scott, T Iwasaki
Structural conservation of the isolated zinc site in archaeal zinc-containing ferredoxins as revealed by X-ray absorption spectroscopic analysis and its evolutionary implications.
J. Biol. Chem. 274, 23160-23168 (1999).

Ishiura, M, Kutsuna S, Aoki S, Iwasaki H, Andersson CR, Tanabe A, Golden SS, Johnson CH, Kondo T
Expression of a gene cluster kaiABC as a circadian feedback process in cyanobacteria.
Science 281, 1519-1523 (1998).

Ouyang, Y, Andersson CR, Kondo T, Golden SS, Johnson CH
Resonating circadian clocks enhance fitness in cyanobacteria.
Proc. Natl. Acad. Sci. USA. 95, 8660-8664 (1998).

Kutsuna S, Kondo T, Aoki T, Ishiura M
A period-extender gene pex that extends the period of the circadian clockin the cyanobacterium Synechococcus sp. strain PCC 7942.
J. Bacteriol. 180, 2167-2174 (1998).

Aoki S, Kondo T, Wada H, Ishiura M
Circadian rhythm of the cyanobacterium Synechocystis sp. PCC 6803 in the dark.
J. Bacteriol. 179, 5751-5755 (1997).

Kondo T, Mori T, Lebedeva NV, Aoki S, Ishiura M, Golden SS
Circadian rhythms in rapidly dividing cyanobacteria.
Science 275 224-227 (1997).

Golden SS, Ishiura M, Johnson CH, Kondo T
Cyanobacterial Circadian Rhythms.
Ann Rev. Plant Physiol. 48, 327-354 (1997).

Tsinoremas NF, Ishiura M, Kondo T, Andersson CR,Tanaka K, Takahashi H,Johnson CH, Golden SS
A sigma factor that modifies the circadian expression of a subset of genes in cyanobacteria.
EMBO J. 15, 2488-2495 (1996).

Liu Y, Tsinoremas NF, Golden SS, KondoT, Johnson CH
Circadian expression of genes involved in the purine biosynthetic pathway of cyanobacterium Synechococcus sp. strain PCC 7942.
Mol. Microbiol. 20, 1071-1081 (1996).

Johnson CH, Knight MR, Kondo T, Masson P, Sedbrook J, Haley A, Trewavas A
Circadian oscillations of cytosolic and chloroplastic free calcium in plants.
Science 269, 1863-1865 (1995).

Aoki S, Kondo T, Ishiura M
Circadian rhythm of dnaK gene expression in cyanobacteria Synechocystis sp. PCC 6803.
J. Bacteriol. 177,5606-5611 (1995).

Liu Y, Tsinoremas NF,Johnson CH, Lebedeva NV, Golden SS, Ishiura M, Kondo T
Circadian orchestration of gene expression in cyanobacteria.
Genes Dev 9,1469-1478 (1995).

Liu Y, Golden SS, Kondo T, Ishiura T, Johnson CH
Bacterial luciferase as a reporter of circadian gene expression in cyanobacteria
J. Bacteriol. 177, 2080-2086 (1995).

Kondo T, Tsinoremas NF, Golden SS, Johnson CH, Kutsuna H, Ishiura M
Circadian clock mutants of cyanobacteria.
Science 266, 1233-1236 (1994).

Kondo T, Ishiura M
Circadian rhythms of cyanobacteria: Monitoring the biological clock of individual colonies by bioluminescence.
J. Bacteriol. 176, 1881-1885 (1994).

Kondo T, Strayer CA, Kulkarni RD, Taylor W, Ishiura M, Golden SS, Johnson CH
Circadian rhythms in prokaryotes: luciferase as a reporter of circadian gene expression in cyanobacteria.
Proc.Natl Acad.Sci. USA. 90, 5672-5676 (1993).